The mRNA expression of IQGAP2 and IQGAP3 in lung cancer subtypes and its correlation with survival of the patients.

<p>(A) and (B): Box and whisker plots showing IQGAP2 mRNA expression in lung cancer subtypes in Oncomine and TCGA database, respectively. X-axis of the plot represents normal vs cancer group, Y-axis represents mRNA expression in log2 median/mean centred intensity. The line in the middle represents the median value. (C) and (D): Box and whisker plots showing IQGAP3 mRNA expression in lung cancer subtypes in Oncomine and TCGA database, respectively. X-axis of the plot represents normal vs cancer group, Y-axis represents mRNA expression in log2 median/mean centred intensity. The line in the middle represents the median value. Differences were examined statistically by two-tailed student’s t-test. (E) and (F): Kaplan-Meier plots showing overall survival (OS) and first progression (FP) in lung cancer and its association with IQGAP2 and IQGAP3 expression levels, respectively. In this graph X-axis denotes, number of patients at risk at specific time (in months) and Y-axis denotes the probability of survival. In red, patients with expression above the median value and in black, patients with expressions below the median value, have been represented. The hazard ratio (HR), 95% CI, p-value ≤ 0.05 were considered significant.