Schematic of asthma model and treatment protocol.

<p>Mice were sensitized by two injections of OVA/alum and challenged by exposure to aerosols of allergen on 3 consecutive days. Two days later mice were intranasally (in) treated with rTgPI-1 (PI) or rTgPI-1 plus OVA (OPI). Controls included non-sensitized mice treated with rTgPI-1 alone (N), and sensitized mice exposed intranasally to PBS (O) or OVA (OO). One week later, mice were re-challenged and analysis was performed 48 h after the last exposure.