Schema of correlative associations between GGAA motifs in EWS/FLI-bound microsatellites for gene activation and repression.

<p>Schematic illustrating EWS/FLI responsiveness at given loci across the genome. (<b>A</b>) Promoter-like (close-range) GGAA-microsatellites positively correlate with EWS/FLI binding and activation of genes in a length dependent manner. (<b>B</b>) Enhancer-like (long-range) GGAA-microsatellites positively correlate with EWS/FLI binding but correlation with transcriptional regulation is only minimal for activated genes. (<b>C</b>) Promoter-like GGAA-microsatellites display no correlation with EWS/FLI binding and transcriptional repression. (<b>D</b>) Enhancer-like GGAA-microsatellites positively correlate with EWS/FLI binding; however, they do not confer gene expression.