TAP1 and TAP2 expression in breast cancer specimens distributed across two tissue microarrays.

<p>TMAs were scored by a certified pathologist for intensity and extent of staining. (A and B) Distribution of maximum TAP1 and TAP2 quick scores, respectively, among individual breast cancer tumor specimens. (C-F) TAP1-stained TMA cores from breast tumor specimens. (C) Grade 3 invasive ductal carcinoma: 0 intensity × 0% extent. (D) Grade 3 invasive ductal carcinoma: 1 intensity × 80% extent. (E) Grade 2 invasive ductal carcinoma: 2 intensity × 60% extent. (F) Grade 3 invasive ductal carcinoma: 3 intensity × 90% extent. (G-J) represents TAP2-stained TMA cores from breast tumor specimens. (G) Grade 2 invasive lobular carcinoma: 0 intensity × 0% extent. (H) Grade 3 invasive ductal carcinoma: 1 intensity × 80% extent. (I) Grade 3 invasive ductal carcinoma: 2 intensity × 90% extent. (J) Grade 3 invasive ductal carcinoma: 3 intensity × 100% extent. TMA indicates tissue microarray. The scale bar in each image denotes 100 μm. (K) Both TAP1 and TAP 2 maximum expression levels were positively correlated by linear regression analysis (R² = 0.6684; <i>P</i> < .001). TAP1 and TAP2 scores, determined by the quick-score method, ranged from 0 to 18.