2013 | Familial liability to psychosis is associated with attenuated dopamine stress signaling in ventromedial prefrontal cortex (conference poster, 2013)

Patients diagnosed with a psychotic disorder and their first-degree relatives display increased reactivity to stress. Although experience of psychosocial stress is associated both with ventromedial prefrontal and mesolimbic dopamine neurotransmission, the role of prefrontal dopamine transmission in the stress psychosis phenotype remains underresearched. The current study aimed at investigating stress-induced in vivo dopamine release in ventromedial prefrontal cortex (vmPFC) of individuals at familial risk for psychosis. first-degree relatives of patients with a psychotic disorder displayed attenuated dopamine stress neuromodulation in vmpfC, possibly reflecting reduced prefrontal regulation of stress-induced mesolimbic dopamine release.<div><br></div><div><b>see also</b></div><div>Lataster, J., Collip, D., Ceccarini, J., Hernaus, D., Haas, D., Booij, L., ... & Myin-Germeys, I. (2013). Familial liability to psychosis is associated with attenuated dopamine stress signaling in ventromedial prefrontal cortex. <i>Schizophrenia bulletin</i>, <i>40</i>(1), 66-77.<br></div><div><br></div><div><b>DOI: 10.1093/schbul/sbs187</b><br>