Platelet activation correlates with the number of PS modifications.

<p>Increase in platelet activation marker A. PAC-1 (activated glycoprotein IIb/IIIa) and B. P-selectin, after 10 min incubation with indicated controls (20 μM ADP, 20 μM TRAP) or 10 μM ODN2395 Thio (+PS), ODN2395 (-PS) and ONs of different length ((AC)5-11; 10–22 mer). Data are shown as boxplots of n = 5 individual data points showing the median value. Dotted lines represent the 95% ULN confidence interval of unstimulated platelets. C. Concentration dependent effect of (AC)8 on increase in platelet PAC-1 and P-selectin surface expression plotted as stimulation index versus control. Data are means ± SD (n = 3).