Asymmetric Total Synthesis of (−)-Clovan-2,9-dione Using Rh(I)-Catalyzed [3 + 2 + 1] Cycloaddition of 1‑Yne-vinylcyclopropane and CO

Jun Yang (2084)
Wenbo Xu (148718)
Qi Cui (603228)
Xing Fan (88299)
Lu-Ning Wang (3286353)
Zhi-Xiang Yu (1505023)

Publication date

November 2017

DOI

10.1021/acs.orglett.7b02656.s002

Abstract

The asymmetric total synthesis of clovan-2,9-dione with a [6.3.1.0<sup>1,5</sup>]dodecane skeleton has been achieved. The synthesis features a Rh(I)-catalyzed [3 + 2 + 1] cycloaddition of 1-yne-vinylcyclopropane (1-yne-VCP) with CO and an intramolecular aldol reaction to obtain the skeleton of the target molecule

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Asymmetric Total Synthesis of (−)-Clovan-2,9-dione Using Rh(I)-Catalyzed [3 + 2 + 1] Cycloaddition of 1‑Yne-vinylcyclopropane and CO

Abstract

Extracted data

Asymmetric Total Synthesis of (−)-Clovan-2,9-dione Using Rh(I)-Catalyzed [3 + 2 + 1] Cycloaddition of 1‑Yne-vinylcyclopropane and CO

Abstract

Extracted data

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