Additional file 12: Figure S12. of A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

Native PAGE to study the interaction between the oncosuppressor p53 and its protein ligands

Lamberti A.
Sgammato R.
Desiderio D.
Punzo C.
Raimo G.
NOVELLINO, ETTORE
CAROTENUTO, ALFONSO
Masullo M.

January 2015

In the present study, we investigated a new approach for studying the interaction between p53 and MD...

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

Shvarts, A.
Bazuine, M.
Dekker, P.B.
Ramos, Y.F.M.
Steegenga, W.T.
Merkx, G.F.M.
Ham, R. van
Houven van Oordt, W. van der
Eb, A.J. van der
Jochemsen, A.G.

January 1997

Contains fulltext : 142231.pdf (publisher's version ) (Open Access

The dual interactions of p53 with MDM2 and p300 : implications for the design of MDM2 inhibitors

Kannan, Srinivasaraghavan
Partridge, Anthony William
Lane, David P.
Verma, Chandra Shekhar

January 2019

Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targete...

Additional file 5: Figure S5. of A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of proteinâprotein interactions identifies a novel putative Mdm2-binding site in p53

Jin Wong (3600983)
Mohammad Alfatah (4584019)
Mei Sin (4584016)
Hong Sim (4584013)
Chandra Verma (23219)
David Lane (311623)
Prakash Arumugam (303310)

November 2017

ABC transporters have distinct substrate specificities. (A) Overnight cultures of either wild-type o...

The MDM2 oncoprotein interacts with the structurally related MDMX protein: Identification and analysis

Sharp, Darcie

January 2000

It is widely accepted that the MDM2 oncoprotein is an inhibitor of the p53 tumor suppressor, via the...

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

Wong, Jin Huei
Alfatah, Mohammad
Sin, Mei Fang
Sim, Hong May
Verma, Chandra Shekhar
Lane, David P.
Arumugam, Prakash

January 2017

Background: Protein–protein interactions (PPIs) are fundamental to the growth and survival of cells ...

Additional file 1 of Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

Bingwu Wang (2038567)
Jian Gao (307118)
Zhongjun Zhao (1413634)
Xuefei Zhong (1572703)
Hao Cui (347051)
Hui Hou (1547212)
Yanping Zhang (153797)
Junnian Zheng (283838)
Jiehui Di (13759299)
Yong Liu (6908)

September 2022

Additional file 1: Figure S1. S9 binds MDM2 in Renca cells. Addition of 100 μM S9 to Renca cells fol...

Inhibitors of MDM2 and MDMX: a structural perspective

Riedinger, Christiane
McDonnell, James

September 2009

p53 is a potent tumor suppressor with a crucial role in preventing uncontrolled cell proliferation a...

MDC1 and p53 interact following DNA damage through the tBRCT domain of MDC1.

Or David Shahar (475848)
Ronen Gabizon (160721)
Oren Feine (262525)
Raphael Alhadeff (196079)
Assaf Ganoth (196074)
Liron Argaman (475849)
Elee Shimshoni (475850)
Assaf Friedler (160766)
Michal Goldberg (252099)

October 2013

<p>(a) A scheme of the different domains of p53. (b) A scheme of the different domains of MDC1. Note...

An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors

Tortorella, Paolo
Laghezza, Antonio
Durante, Milena
GOMEZ MONTERREY, ISABEL MARIA
Bertamino, Alessia
Campiglia, Pietro
Loiodice, Fulvio
Daniele, Simona
Martini, Claudia
Agamennone, Mariangela

January 2016

The p53-MDM2 interaction is a well-known protein-protein contact, and its disruption is a key event ...

Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA

Burch, L.R.
Midgley, C.A.
Currie, R.A.
Lane, D.P.
Hupp, T.R.

April 2000

AbstractBiochemical characterisation of the interaction of mdm2 protein with p53 protein has demonst...

Additional file 1: of Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence

Durai Sundar (186005)
Yue Yu (260119)
Shashank Katiyar (6405416)
Jayarani Putri (6405422)
Jaspreet Dhanjal (4055248)
Jia Wang (51945)
Anissa Sari (6405431)
Evangelos Kolettas (1701604)
Sunil Kaul (694692)
Renu Wadhwa (185998)

February 2019

Table S1. PDB IDs of different p53 protein variants and their structural resolution. Table S2. H-bon...

Precise mapping of the tms1 binding site on p53

Wagner, Peter
Fuchs, Annette
Prowald, Alexandra
Montenarh, Mathias
Nastainczyk, Wolfgang

December 1995

AbstractOriginally identified as multicopy suppressor of a lethal growth arrest caused by expression...

MDM2 interacts with MDMX through their RING finger domains

Tanimura, Shyu
Ohtsuka, Satoshi
Mitsui, Kaoru
Shirouzu, Kazuo
Yoshimura, Akihiko
Ohtsubo, Motoaki

March 1999

AbstractThe N-terminus of MDM2 proto-oncoprotein interacts with p53 and down modulates p53 activity ...

SEE PROFILE

Xinjiang Wang
Available From Xinjiang Wang

January 2016

lity t p lt ti n th do as a substrate of Mdm2/MdmX E3 complex. The insufficiency of Mdm2 for p53 pol...

Native PAGE to study the interaction between the oncosuppressor p53 and its protein ligands

Lamberti A.
Sgammato R.
Desiderio D.
Punzo C.
Raimo G.
NOVELLINO, ETTORE
CAROTENUTO, ALFONSO
Masullo M.

January 2015

In the present study, we investigated a new approach for studying the interaction between p53 and MD...

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

Shvarts, A.
Bazuine, M.
Dekker, P.B.
Ramos, Y.F.M.
Steegenga, W.T.
Merkx, G.F.M.
Ham, R. van
Houven van Oordt, W. van der
Eb, A.J. van der
Jochemsen, A.G.

January 1997

Contains fulltext : 142231.pdf (publisher's version ) (Open Access

The dual interactions of p53 with MDM2 and p300 : implications for the design of MDM2 inhibitors

Kannan, Srinivasaraghavan
Partridge, Anthony William
Lane, David P.
Verma, Chandra Shekhar

January 2019

Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targete...

Additional file 5: Figure S5. of A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of proteinâprotein interactions identifies a novel putative Mdm2-binding site in p53

Jin Wong (3600983)
Mohammad Alfatah (4584019)
Mei Sin (4584016)
Hong Sim (4584013)
Chandra Verma (23219)
David Lane (311623)
Prakash Arumugam (303310)

November 2017

ABC transporters have distinct substrate specificities. (A) Overnight cultures of either wild-type o...

The MDM2 oncoprotein interacts with the structurally related MDMX protein: Identification and analysis

Sharp, Darcie

January 2000

It is widely accepted that the MDM2 oncoprotein is an inhibitor of the p53 tumor suppressor, via the...

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

Wong, Jin Huei
Alfatah, Mohammad
Sin, Mei Fang
Sim, Hong May
Verma, Chandra Shekhar
Lane, David P.
Arumugam, Prakash

January 2017

Background: Protein–protein interactions (PPIs) are fundamental to the growth and survival of cells ...

Additional file 1 of Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

Bingwu Wang (2038567)
Jian Gao (307118)
Zhongjun Zhao (1413634)
Xuefei Zhong (1572703)
Hao Cui (347051)
Hui Hou (1547212)
Yanping Zhang (153797)
Junnian Zheng (283838)
Jiehui Di (13759299)
Yong Liu (6908)

September 2022

Additional file 1: Figure S1. S9 binds MDM2 in Renca cells. Addition of 100 μM S9 to Renca cells fol...

Inhibitors of MDM2 and MDMX: a structural perspective

Riedinger, Christiane
McDonnell, James

September 2009

p53 is a potent tumor suppressor with a crucial role in preventing uncontrolled cell proliferation a...

MDC1 and p53 interact following DNA damage through the tBRCT domain of MDC1.

Or David Shahar (475848)
Ronen Gabizon (160721)
Oren Feine (262525)
Raphael Alhadeff (196079)
Assaf Ganoth (196074)
Liron Argaman (475849)
Elee Shimshoni (475850)
Assaf Friedler (160766)
Michal Goldberg (252099)

October 2013

<p>(a) A scheme of the different domains of p53. (b) A scheme of the different domains of MDC1. Note...

An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors

Tortorella, Paolo
Laghezza, Antonio
Durante, Milena
GOMEZ MONTERREY, ISABEL MARIA
Bertamino, Alessia
Campiglia, Pietro
Loiodice, Fulvio
Daniele, Simona
Martini, Claudia
Agamennone, Mariangela

January 2016

The p53-MDM2 interaction is a well-known protein-protein contact, and its disruption is a key event ...

Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA

Burch, L.R.
Midgley, C.A.
Currie, R.A.
Lane, D.P.
Hupp, T.R.

April 2000

AbstractBiochemical characterisation of the interaction of mdm2 protein with p53 protein has demonst...

Additional file 1: of Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence

Durai Sundar (186005)
Yue Yu (260119)
Shashank Katiyar (6405416)
Jayarani Putri (6405422)
Jaspreet Dhanjal (4055248)
Jia Wang (51945)
Anissa Sari (6405431)
Evangelos Kolettas (1701604)
Sunil Kaul (694692)
Renu Wadhwa (185998)

February 2019

Table S1. PDB IDs of different p53 protein variants and their structural resolution. Table S2. H-bon...

Precise mapping of the tms1 binding site on p53

Wagner, Peter
Fuchs, Annette
Prowald, Alexandra
Montenarh, Mathias
Nastainczyk, Wolfgang

December 1995

AbstractOriginally identified as multicopy suppressor of a lethal growth arrest caused by expression...

MDM2 interacts with MDMX through their RING finger domains

Tanimura, Shyu
Ohtsuka, Satoshi
Mitsui, Kaoru
Shirouzu, Kazuo
Yoshimura, Akihiko
Ohtsubo, Motoaki

March 1999

AbstractThe N-terminus of MDM2 proto-oncoprotein interacts with p53 and down modulates p53 activity ...

SEE PROFILE

Xinjiang Wang
Available From Xinjiang Wang

January 2016

lity t p lt ti n th do as a substrate of Mdm2/MdmX E3 complex. The insufficiency of Mdm2 for p53 pol...

Native PAGE to study the interaction between the oncosuppressor p53 and its protein ligands

Lamberti A.
Sgammato R.
Desiderio D.
Punzo C.
Raimo G.
NOVELLINO, ETTORE
CAROTENUTO, ALFONSO
Masullo M.

January 2015

In the present study, we investigated a new approach for studying the interaction between p53 and MD...

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

Shvarts, A.
Bazuine, M.
Dekker, P.B.
Ramos, Y.F.M.
Steegenga, W.T.
Merkx, G.F.M.
Ham, R. van
Houven van Oordt, W. van der
Eb, A.J. van der
Jochemsen, A.G.

January 1997

Contains fulltext : 142231.pdf (publisher's version ) (Open Access

The dual interactions of p53 with MDM2 and p300 : implications for the design of MDM2 inhibitors

Kannan, Srinivasaraghavan
Partridge, Anthony William
Lane, David P.
Verma, Chandra Shekhar

January 2019

Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targete...

Additional file 12: Figure S12. of A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

Abstract

Extracted data

Additional file 12: Figure S12. of A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

Abstract

Extracted data

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