Frequency distribution of mutations in HCM-causing genes.

<p>The mutation distribution in 13 of the 18 HCM causative genes based on mutation class, including missense, nonsense, frameshift mutations and intronic and UTR variations (<b>A</b>). Distribution of mutation types among the causative genes (<b>B</b>), with missense and nonsense mutation contributing more than 80% of all classes of mutations.