Comparisons of ERGs at two time-points following AAV vector treatment.

<p>As a mouse model of achromatopsia, <i>cpfl5</i> mice show selective loss of cone ERG responses. Scotopic (A) and photopic ERGs (B) were recorded at 1 and 3 months following treatment with AAV8 (Y447, 733F + T494V) (red), AAV2 (Y272, 444, 500, 730F + T491V) (green), or AAV8 (Y447, 733F) (blue). Recovered photopic ERG (cone-mediated) amplitudes were compared among groups (C). (D) Photopic-ERG dose response of the AAV-vector dilutions. The <i>cpfl5</i> mice were treated in one eye at P14 and evaluated at 1 month after subretinal injection. Age-matched WT and untreated <i>cpfl5</i> eyes were used as controls (n = 6 mice). P, postnatal day. *indicates <i>P</i> < 0.05, **indicates <i>P</i> < 0.01, ***indicates <i>P</i> < 0.001, NS = no statistical difference.