ATRA therapy affects viability of MPNST cells in a dose-dependent manner.

<p>Viability of cells under ATRA treatment was monitored by MTT assay on day 7 of treatment. T265 cells showed reduced viability at high ATRA concentrations (25 μM and 50 μM) and enhanced viability at low ATRA concentrations (5 μM and 10 μM). S462 cells demonstrated reduced viability at all ATRA concentrations. MCF-7 cells used as control were sensitive to ATRA treatment at all concentrations. In contrast, normal rat Schwan cells displayed no change of viability under ATRA treatment. Bars represent mean values of 3–4 repeated measurements within each cell line.