Palladium-Catalyzed [5 + 2] Cycloaddition of Vinyloxiranes with Sulfamate-Derived Cyclic Imines To Construct 1,3-Oxazepine Heterocycles
- Yang Wu (66682)
- Chunhao Yuan (1538038)
- Chang Wang (328274)
- Biming Mao (2917877)
- Hao Jia (196106)
- Xing Gao (112909)
- Jianning Liao (3896788)
- Feng Jiang (95012)
- Leijie Zhou (1695967)
- Qijun Wang (3896791)
- Hongchao Guo (1538041)
Publication date
November 2017
DOIAbstract
Palladium-catalyzed [5 + 2] cycloaddition of 2-aryl-2-vinyloxiranes with sulfamate-derived cyclic imines is described. The zwitterionic allylpalladium intermediates act as five-membered synthon to react with sulfamate-derived cyclic imines to furnish [5 + 2] cycloaddition, giving 1,3-oxazepine derivatives in moderate to excellent yields with excellent regioselectivities
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