<p>CD8<sup>+</sup> T cells from four healthy, eight LTBI, and four Mtb-infected donors were incubated in an IFN-γ ELISPOT plate with autologous DC pulsed with each of the 28 validated Mtb peptides. Shown are the IFN-γ spot forming units for the 12 peptides for which at least one donor responded.</p
Studies of mouse models of tuberculosis (TB) infection have indicated a central role for MHC class I...
© 2019 Michael Nicholas Tod SouterUnconventional T cells are evolutionarily conserved populations of...
<p>(A) EBNA2-specific responses. Top left panel: In vitro expanded, CD8-enriched polyclonal T cells ...
<p>PBMC isolated from 40 healthy BCG-vaccinated individuals were stimulated with Mtb cell wall antig...
<p>A–B) Mtb-infected DC, BEAS-2B cells, or LAEC (MOI:10) were used as APCs in an IFN-γ ELISPOT assay...
<p>PBMCs were initially screened by <i>ex vivo</i> ELISpot and the CD4<sup>+</sup> and CD8<sup>+</su...
MHC class I-restricted CD8 cytotoxic T lymphocytes (CTL) are essential for protective immunity to My...
<p>DCs autologous to D454 and expressing HLA-B08 were transduced with either a control adenoviral ve...
<p>(A) IFN-γ spots, each representing a CD8 T cell responding with IFN-γ production, formed upon sen...
<p>IFNγ ELISpot responses specific to Mtb antigens following injection of MVATG18598 in <b>(A)</b> B...
More than 2 billion individuals are latently infected with Mycobacterium tuberculosis (Mtb). Knowled...
<div><p>Identification of CD8<sup>+</sup> T cell antigens/epitopes expressed by human pathogens with...
CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M....
<p>IFNγ production by polyclonal CD4<sup>+</sup> (a) or CD8<sup>+</sup> (b) T cells after co-culture...
Studies of mouse models of tuberculosis (TB) infection have indicated a central role for MHC class I...
Studies of mouse models of tuberculosis (TB) infection have indicated a central role for MHC class I...
© 2019 Michael Nicholas Tod SouterUnconventional T cells are evolutionarily conserved populations of...
<p>(A) EBNA2-specific responses. Top left panel: In vitro expanded, CD8-enriched polyclonal T cells ...
<p>PBMC isolated from 40 healthy BCG-vaccinated individuals were stimulated with Mtb cell wall antig...
<p>A–B) Mtb-infected DC, BEAS-2B cells, or LAEC (MOI:10) were used as APCs in an IFN-γ ELISPOT assay...
<p>PBMCs were initially screened by <i>ex vivo</i> ELISpot and the CD4<sup>+</sup> and CD8<sup>+</su...
MHC class I-restricted CD8 cytotoxic T lymphocytes (CTL) are essential for protective immunity to My...
<p>DCs autologous to D454 and expressing HLA-B08 were transduced with either a control adenoviral ve...
<p>(A) IFN-γ spots, each representing a CD8 T cell responding with IFN-γ production, formed upon sen...
<p>IFNγ ELISpot responses specific to Mtb antigens following injection of MVATG18598 in <b>(A)</b> B...
More than 2 billion individuals are latently infected with Mycobacterium tuberculosis (Mtb). Knowled...
<div><p>Identification of CD8<sup>+</sup> T cell antigens/epitopes expressed by human pathogens with...
CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M....
<p>IFNγ production by polyclonal CD4<sup>+</sup> (a) or CD8<sup>+</sup> (b) T cells after co-culture...
Studies of mouse models of tuberculosis (TB) infection have indicated a central role for MHC class I...
Studies of mouse models of tuberculosis (TB) infection have indicated a central role for MHC class I...
© 2019 Michael Nicholas Tod SouterUnconventional T cells are evolutionarily conserved populations of...
<p>(A) EBNA2-specific responses. Top left panel: In vitro expanded, CD8-enriched polyclonal T cells ...