4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of readily accessible 3-alkylidene-1,2-diazetidines. Using difluorocarbene, generated from TMSCF<sub>3</sub>/NaI, these spirocycles were produced in yields up to 97% by stereospecific addition across the alkene. Lower yields (up to 64%) were observed using more reactive dichlorocarbene, due to competitive insertion of the carbene into the N–N bond. Larger 1,2-diazaspiro[3.3]heptanes are produced by [2 + 2] cycloaddition of 3-alkylidene-1,2-diazetidines with tetracyanoethylene (TCNE) in up to 99% yield
Multicomponent condensation of N-diphenylphosphinoylimines, alkynes, zirconocene hydrochloride, and ...
<div><p></p><p>The 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the reactio...
The FeCl<sub>3</sub>-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expan...
4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of ...
4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of re...
4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of re...
The nitrogen containing spiro-heterocycle is one of the privileged synthetic motif that constitutes ...
AbstractThe nitrogen containing spiro-heterocycle is one of the privileged synthetic motif that cons...
Asymmetric synthesis of 1-substituted 2,6-diazaspiro[3.3]heptane is described. This methodology aff...
A carbene cascade reaction that constructs functionalized bridged bicyclic systems from alkynyl diaz...
A convenient and simple three step synthesis of 1,7-diazaspiro[5.5]undecane via Claisen condensation...
1,2-Diaza-1,3-butadienes react with 2-mercapto-2-thiazoline to give 1,4-adducts that in turn produce...
An efficient two-step synthesis of a wide range of 3-methylene-1,2-diazetidines has been developed t...
A regio- and diastereoselective 1,3-dipolar cycloaddition of 2H-azirines with azomethine ylides gene...
Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates, and re...
Multicomponent condensation of N-diphenylphosphinoylimines, alkynes, zirconocene hydrochloride, and ...
<div><p></p><p>The 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the reactio...
The FeCl<sub>3</sub>-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expan...
4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of ...
4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of re...
4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of re...
The nitrogen containing spiro-heterocycle is one of the privileged synthetic motif that constitutes ...
AbstractThe nitrogen containing spiro-heterocycle is one of the privileged synthetic motif that cons...
Asymmetric synthesis of 1-substituted 2,6-diazaspiro[3.3]heptane is described. This methodology aff...
A carbene cascade reaction that constructs functionalized bridged bicyclic systems from alkynyl diaz...
A convenient and simple three step synthesis of 1,7-diazaspiro[5.5]undecane via Claisen condensation...
1,2-Diaza-1,3-butadienes react with 2-mercapto-2-thiazoline to give 1,4-adducts that in turn produce...
An efficient two-step synthesis of a wide range of 3-methylene-1,2-diazetidines has been developed t...
A regio- and diastereoselective 1,3-dipolar cycloaddition of 2H-azirines with azomethine ylides gene...
Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates, and re...
Multicomponent condensation of N-diphenylphosphinoylimines, alkynes, zirconocene hydrochloride, and ...
<div><p></p><p>The 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the reactio...
The FeCl<sub>3</sub>-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expan...