Expression level of IL-22 receptor and binding protein in the spleen of PIA rats.

<p><b>(A)</b> Expression of IL-22R1 and IL-22BP at 28 days in the spleen from rats (n = 10 to 13 for each group) were measured by real-time qPCR. Relative mRNA expression was normalized by β-actin. <b>(B)</b> The ratio of IL-22R1/IL-22BP was evaluated from normalized expression. The IL-22R1/IL-22BP ratios were shown as means ± SEM. Levels of significance between the PIA group and control group were calculated by using Mann-Whitney U test (*** <i>P</i>< 0.001).