Dynamics of CD4 and CD8 T cell responses in the described patient.

<p>(A) Proportions of CD4 (upper plots) and CD8 (lower plots) T cells specific for the indicated HIV-1 gene product. Color coding reflects time of sample collection. HIV-1-specific T cell responses were identified based on antigen-specific IFNγ secretion (left plots) or IL-2 secretion (right plots). (B) Proportions of total CD4 and CD8 T cells, and indicated T cell subsets, within CD4 and CD8 T cells. (C) Heatmaps reflecting the longitudinal evolution of the proportions of indicated CD4 (left plot) and CD8 (right plot) T cell subsets expressing PD-1 or CD38/HLA-DR. (D) Proportions of FoxP3+ regulatory T cells with indicated phenotypic characteristics. ATI, analytic treatment interruption; Tcm, central memory T cells; Teff, terminally differentiated T cells; Tem, effector memory T cells; Treg, regulatory T cells; Tscm, T memory stem cells.