Additional file 1: Figures S1–S12. of Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Figure S1. Correlation of gene expression measurements derived using either RNA-seq or 3′-seq of matched ovary or testis samples. Figure S2. Principal component analysis of 3′-seq and RNA-seq data. Figure S3. Distribution of reads and 3′ ends onto genomic features. Figure S4. Examples of a gene with diverse APA patterns. Figure S5. Rare events maintain a signature of bona fide 3′ ends. Figure S6. Un-scaled analysis of weighted 3′ UTR length. Figure S7. Additional examples of APA dynamics in cell lines. Figure S8. APA dynamics during embryogenesis. Figure S9. Nucleotide distribution around D. yakuba and D. virilis 3′ ends. Figure S10. Numbers of additional miRNA sites and example of deeply conserved targets. Figure S11. Nucleotide distribution around D. melanogaster 3′ ends subdivided by class. Figure S12. Comparison of structural forming potential of the proximal and distal PAS-polyA regions. (PDF 4462 kb