Osteoarthritis Cynomolgus monkey model.

<p>A) Histological appearance of pancreas, spleen, kidney, colon, smooth and skeletal muscle, heart and lung tissues from animals euthanized after MSCs injections. Sections at 4μm embedded in paraffin stained with haematoxylin and eosin (H-E) were shown. All pictures have the same magnification, bar represents 20 μm. B) Microscopic study form health and injured knees from Cynomolgus monkey model after sacrificing them. Synovial membrane and cartilage sections from animals of the study were shown. Histological appearance of tissues at 4μm embedded in paraffin to keep their consistency. Synovial membrane stained with haematoxylin and eosin (H-E) (magnification 20x) from right knee which was healthy on the left and left knee which was injured to provoke OA pathology on the right (up). Cartilage was stained with Safranine O (magnification 10x) from right knee which was healthy on the left and left knee which was injured to provoke OA pathology on the right (bottom). C) Macroscopic study from health and injured femoral condyles from Cynomolgus monkey model after sacrificing them. The arrow points lesion area.