Metabolex-36 and AZ13581837 increased insulin secretion in IVGTT in lean mice.

<p>Insulin (<b>A</b>) and blood glucose (<b>C</b>) levels following an intravenous glucose challenge after oral administration of Metabolex-36 and AZ13581837 in lean female mice and corresponding AIR (<b>B</b>) and glucose elimination (<b>D</b>). Data represent six (Metabolex-36, n = 33, vehicle n = 34) and two (AZ13581837, n = 14) independent experiments and data are presented as mean ± SEM. Plasma levels of total GLP-1 (<b>E</b>) at time point was determined in separate experiments with n = 10 mice per group. ***p<0.001 and **p<0.01versus vehicle control.