Alignment of the human C/EBP family.

<p>Fully- and partially-conserved residues are in red and yellow, respectively. The secondary structure of the C/EBPα bZIP domain is shown above the sequences, while the numbering below corresponds to CHOP. The segments with α-helical propensity as identified by NMR (see below) are in green. Red and blue circles below the sequence indicate inactivating and activating phosphorylations in CHOP [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0189171#pone.0189171.ref007" target="_blank">7</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0189171#pone.0189171.ref008" target="_blank">8</a>], while asterisks highlight unique changes in its DNA-binding domain. Figure prepared with ESPript (<a href="http://espript.ibcp.fr/" target="_blank">http://espript.ibcp.fr</a>).