Effects of SARM-2f on mouse voluntary running.

<p>The outline of the voluntary running test is shown in Fig 6A. Running distance during 2 weeks of treatment with TP or SARM-2f was calculated by the formula described in the Materials and methods section (B). (B) Running count average in day13–14. (C) Levator ani muscle weight measured after 2-week dosing. The drug was administered to castrated mice with DHEA for 2 weeks. The measurement technique is described in the Materials and methods section. Data are shown as the means ± SD (n = 8). *P < 0.025 vs. the ORX (vehicle treated castrated mice) group using the Williams test. #P < 0.05 vs the ORX by student t-test.