Antigen-specific increase in interaction force between dendritic cells and T-cells.

<p>Bone marrow-derived dendritic cells were pulsed with 1 mg/ml OVA (filled symbols) before addition of OVA-specific OT-II T-cells. Control cells remained un-pulsed (empty symbols). The relative force required to separate T-cells and dendritic cells after 30 seconds of interaction was determined for 15 cell pairs using the approach outlined in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188581#pone.0188581.g002" target="_blank">Fig 2</a>. The black lines represent the median average of the measurements. The dotted grey line the minimum and maximum measurement range. A significant difference in relative interaction force is seen as evidenced by the Mann Whitney test (p ≤ 0.005).