Changes in the survival rate (upper panels) and body weight (lower panels) in BALB/c mice treated with antiserum after lethal PRV-MB infection.

<p>The PRV-MB-1.0×10⁵ PFU mice were treated with the intraperitoneal administration of antiserum once daily during periods surrounded by the gray boxes (5 mice per group). Antiserum with a PRV-MB-specific serum neutralizing antibody titer of 1:10,240 was diluted 4-fold with PBS. The volume of the antiserum administered daily was 100 μL. The treatment was initiated at just after 1 h after the virus challenge (B) or from the 1st (C), 2nd (D), 3rd (E), and 4th (F) DPI. The control mice were administered the same volume of control serum, PRV antibody negative mouse serum diluted with PBS (A). Error bars indicate the standard error.