Effect of oral DFMO on polyamine levels in tumor-bearing mice.

<p>Intracellular polyamine levels (putrescine, spermidine, spermine) were analyzed in tumor tissue (<b>A</b>) and blood plasma (<b>B</b>) of DFMO-treated and untreated mice using reverse-phase HPLC. Intracellular polyamines were quantified and expressed as nmol/mg protein (<b>A</b>) or nmol/ml plasma (<b>B</b>). Standard errors are indicated (+/- S.E.). Put, putrescine; Spd, spermidine; Spm, spermine.