Chronic EHT treatment prevents Aβ-induced impairment of long-term potentiation.

<p><b>(</b>A-B) Time course of averaged Schaffer collateral fEPSP responses (± SEM) in hippocampal slices prepared from animals fed control or EHT-containing diets and treated with either vehicle or 100 nM Aβ (horizontal bar) 20 min prior to delivery of theta-burst stimulation (arrow). (A) Aβ treatment significantly reduces potentiated responses following TBS in slices prepared from animals on control diets (2-way RM-ANOVA for treatment with time and treatment as factors: F(1,29) = 8.913, P = 0.0057). (B) Mice fed diets containing 0.01% EHT are resistant to Aβ-induced LTP impairment (2-way RM-ANOVA for treatment with time and treatment as factors: F(1,26) = 0.0943, P = 0.7612). C) Input/output (2-way RM-ANOVA for treatment with stimulus and treatment as factors: F(1,57) = 0.5466, P = 0.4628) (N = 31 control, 28 0.01% EHT).