Additional file 5: Figure S4. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Additional file 3: of Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina Mumin (6262541)
Neele Drobnitzky (6262547)
Agata Patel (6262553)
Luiza Lourenco (6262556)
Fiona Cahill (6262562)
Yanyan Jiang (253354)
Anthony Kong (94738)
Anderson Ryan (482874)

January 2019

Table S2. Compounds that were selectively cytotoxic to parental Hs578T cells compared with HSP90i-re...

Additional file 1: Figure S1. of Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

Gaurab Chakrabarti (3425915)
Zachary Moore (3425921)
Xiuquan Luo (579204)
Mariya Ilcheva (3425912)
Aktar Ali (412002)
Mahesh Padanad (3425930)
Yunyun Zhou (1780960)
Yang Xie (46489)
Sandeep Burma (122515)
Pier Scaglioni (3425909)
Lewis Cantley (2653345)
Ralph DeBerardinis (3425927)
Alec Kimmelman (3425933)
Costas Lyssiotis (3425918)
David Boothman (3425924)

October 2015

ß-Lap mechanism and GOT2 to GLUD1 Kaplan–Meier curve. (A) ß-lap mechanism of action. In the cytosol ...

Additional file 2: Figure S2. of GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

Hiromi Ito (505919)
Osamu Ichiyanagi (3490328)
Sei Naito (3490322)
Vladimir Bilim (3490316)
Yoshihiko Tomita (2511928)
Tomoyuki Kato (3490325)
Akira Nagaoka (3490319)
Norihiko Tsuchiya (95704)

July 2016

Different effects of GSK-3 inhibition on Akt and 4EBP1 phosphorylation. (A) ACHN cells were treated ...

Additional file 2: Figure S1. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Qiuran Xu (4103755)
Jianfeng Tu (4103758)
Changwei Dou (3554573)
Jun Zhang (48506)
Liu Yang (23752)
Xin Liu (43569)
Kefeng Lei (4708894)
Zhikui Liu (3554570)
Yufeng Wang (274657)
Lijie Li (1438762)
Hangxing Bao (4103752)
Jiahui Wang (746367)
Kangsheng Tu (428934)

December 2017

Knockdown of HSP90 reduced the protein level of PKM2. Hep3B cells were transfected with HSP90 shRNA ...

Additional file 4: Figure S3. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Qiuran Xu (4103755)
Jianfeng Tu (4103758)
Changwei Dou (3554573)
Jun Zhang (48506)
Liu Yang (23752)
Xin Liu (43569)
Kefeng Lei (4708894)
Zhikui Liu (3554570)
Yufeng Wang (274657)
Lijie Li (1438762)
Hangxing Bao (4103752)
Jiahui Wang (746367)
Kangsheng Tu (428934)

December 2017

MG132 restored the protein level of PKM2 induced by HSP90 knockdown. MG-132 was used to inhibit the ...

Additional file 1: Figure S1. of Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance

Enxuan Jing (4815984)
Pragalath Sundararajan (4815978)
Ishita Majumdar (4815981)
Suwagmani Hazarika (4815969)
Samantha Fowler (4815987)
Angela Szeto (4815972)
Stephane Gesta (4715982)
Armando Mendez (4815975)
Vivek Vishnudas (3848308)
Rangaprasad Sarangarajan (3848311)
Niven Narain (3848314)

February 2018

Knockdown of Hsp90ab1 decreases PDH catalytic subunit phosphorylation. Skeletal muscle of DIO mice w...

Additional file 2: Figure S2. of Hsp90Î˛ promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma

Jing Meng (586670)
Yanrong Liu (537906)
Jingxia Han (3879847)
Qiang Tan (1758361)
Shuang Chen (12981)
Kailiang Qiao (3879850)
Honggang Zhou (3879853)
Tao Sun (91038)
Cheng Yang (273624)

March 2017

Inhibition of HHL-5 (a), SMMC-7721 (b), PLC-PRF-5 (c), and BEL-7402 (d) cells via NVP-BEP800 treatme...

Additional file 3: Figure S1. of Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

Hirofumi Bekki (3501791)
Kenichi Kohashi (3501809)
Akira Maekawa (3501797)
Yuichi Yamada (3501800)
Hidetaka Yamamoto (3501794)
Katsumi Harimaya (3501803)
Michiyuki Hakozaki (582996)
Kazuki Nabeshima (3501806)
Yukihide Iwamoto (89775)
Yoshinao Oda (629764)

October 2015

Protein expression analysis by Western blot analysis. p-Akt, p-mTOR, p-S6RP and p-4EBP were detected...

Additional file 2: of Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina Mumin (6262541)
Neele Drobnitzky (6262547)
Agata Patel (6262553)
Luiza Lourenco (6262556)
Fiona Cahill (6262562)
Yanyan Jiang (253354)
Anthony Kong (94738)
Anderson Ryan (482874)

January 2019

Figure S1. Positive correlation of pSTAT3 expression with HSP90i sensitivity. A scatter plot display...

Additional file 1: of Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina Mumin (6262541)
Neele Drobnitzky (6262547)
Agata Patel (6262553)
Luiza Lourenco (6262556)
Fiona Cahill (6262562)
Yanyan Jiang (253354)
Anthony Kong (94738)
Anderson Ryan (482874)

January 2019

Table S1. The top 20 most significantly enriched pathways seen in HSP90i-resistant clones. Pathway e...

Additional file 4: Figure S4. of PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 regulates hypoxia-induced HIF-1α accumulation. A, B, pancreatic cancer cells transduced with a ...

Additional file 4: Figure S3. of Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors

Charan Devarakonda (3587093)
Daniel Kita (3587096)
Kathryn Phoenix (3587099)
Kevin Claffey (33353)

September 2015

Immunoprecipitation of HSP90 from xenograft tumor lysates using HCAb2. RIPA lysates of xenograft tum...

Additional file 2: Table S2. of Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

Hirofumi Bekki (3501791)
Kenichi Kohashi (3501809)
Akira Maekawa (3501797)
Yuichi Yamada (3501800)
Hidetaka Yamamoto (3501794)
Katsumi Harimaya (3501803)
Michiyuki Hakozaki (582996)
Kazuki Nabeshima (3501806)
Yukihide Iwamoto (89775)
Yoshinao Oda (629764)

October 2015

Immunohistochemical Results and Their Statistical Analysis. EFS, event-free survival; LI, labeling i...

Additional file 2: of HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Xin Xiao (117295)
Wei Wang (17594)
Yuqian Li (577378)
Di Yang (126672)
Xiaokang Li (158714)
Chao Shen (520343)
Yan Liu (25061)
Xianzhu Ke (4566235)
Shuo Guo (5696564)
Zheng Guo (14989)

August 2018

Figure S2. JNK or p38 inhibitors decreased the cell apoptosis. A, control shRNA/HSP90AA1 shRNA trans...

Additional file 5: of Mutational analysis of selected high-grade malignancies in a premenopausal gynecologic cancer population: a potential for targeted therapies?

Lauren Pinckney (5712251)
Justin Collins (5712254)
Christine Schammel (5712257)
Matt Gevaert (2370316)
David Schammel (5712260)
W. Edenfield (5712263)
Jeffrey Elder (5712266)
Larry Puls (5712269)

September 2018

Figure S2. GPR124, ALK and KMT2D proteins converge on HSP90AA1. An evaluation of the potential role ...

Additional file 3: of Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina Mumin (6262541)
Neele Drobnitzky (6262547)
Agata Patel (6262553)
Luiza Lourenco (6262556)
Fiona Cahill (6262562)
Yanyan Jiang (253354)
Anthony Kong (94738)
Anderson Ryan (482874)

January 2019

Table S2. Compounds that were selectively cytotoxic to parental Hs578T cells compared with HSP90i-re...

Additional file 1: Figure S1. of Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

Gaurab Chakrabarti (3425915)
Zachary Moore (3425921)
Xiuquan Luo (579204)
Mariya Ilcheva (3425912)
Aktar Ali (412002)
Mahesh Padanad (3425930)
Yunyun Zhou (1780960)
Yang Xie (46489)
Sandeep Burma (122515)
Pier Scaglioni (3425909)
Lewis Cantley (2653345)
Ralph DeBerardinis (3425927)
Alec Kimmelman (3425933)
Costas Lyssiotis (3425918)
David Boothman (3425924)

October 2015

ß-Lap mechanism and GOT2 to GLUD1 Kaplan–Meier curve. (A) ß-lap mechanism of action. In the cytosol ...

Additional file 2: Figure S2. of GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

Hiromi Ito (505919)
Osamu Ichiyanagi (3490328)
Sei Naito (3490322)
Vladimir Bilim (3490316)
Yoshihiko Tomita (2511928)
Tomoyuki Kato (3490325)
Akira Nagaoka (3490319)
Norihiko Tsuchiya (95704)

July 2016

Different effects of GSK-3 inhibition on Akt and 4EBP1 phosphorylation. (A) ACHN cells were treated ...

Additional file 2: Figure S1. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Qiuran Xu (4103755)
Jianfeng Tu (4103758)
Changwei Dou (3554573)
Jun Zhang (48506)
Liu Yang (23752)
Xin Liu (43569)
Kefeng Lei (4708894)
Zhikui Liu (3554570)
Yufeng Wang (274657)
Lijie Li (1438762)
Hangxing Bao (4103752)
Jiahui Wang (746367)
Kangsheng Tu (428934)

December 2017

Knockdown of HSP90 reduced the protein level of PKM2. Hep3B cells were transfected with HSP90 shRNA ...

Additional file 4: Figure S3. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Qiuran Xu (4103755)
Jianfeng Tu (4103758)
Changwei Dou (3554573)
Jun Zhang (48506)
Liu Yang (23752)
Xin Liu (43569)
Kefeng Lei (4708894)
Zhikui Liu (3554570)
Yufeng Wang (274657)
Lijie Li (1438762)
Hangxing Bao (4103752)
Jiahui Wang (746367)
Kangsheng Tu (428934)

December 2017

MG132 restored the protein level of PKM2 induced by HSP90 knockdown. MG-132 was used to inhibit the ...

Additional file 1: Figure S1. of Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance

Enxuan Jing (4815984)
Pragalath Sundararajan (4815978)
Ishita Majumdar (4815981)
Suwagmani Hazarika (4815969)
Samantha Fowler (4815987)
Angela Szeto (4815972)
Stephane Gesta (4715982)
Armando Mendez (4815975)
Vivek Vishnudas (3848308)
Rangaprasad Sarangarajan (3848311)
Niven Narain (3848314)

February 2018

Knockdown of Hsp90ab1 decreases PDH catalytic subunit phosphorylation. Skeletal muscle of DIO mice w...

Additional file 2: Figure S2. of Hsp90Î˛ promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma

Jing Meng (586670)
Yanrong Liu (537906)
Jingxia Han (3879847)
Qiang Tan (1758361)
Shuang Chen (12981)
Kailiang Qiao (3879850)
Honggang Zhou (3879853)
Tao Sun (91038)
Cheng Yang (273624)

March 2017

Inhibition of HHL-5 (a), SMMC-7721 (b), PLC-PRF-5 (c), and BEL-7402 (d) cells via NVP-BEP800 treatme...

Additional file 3: Figure S1. of Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

Hirofumi Bekki (3501791)
Kenichi Kohashi (3501809)
Akira Maekawa (3501797)
Yuichi Yamada (3501800)
Hidetaka Yamamoto (3501794)
Katsumi Harimaya (3501803)
Michiyuki Hakozaki (582996)
Kazuki Nabeshima (3501806)
Yukihide Iwamoto (89775)
Yoshinao Oda (629764)

October 2015

Protein expression analysis by Western blot analysis. p-Akt, p-mTOR, p-S6RP and p-4EBP were detected...

Additional file 2: of Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina Mumin (6262541)
Neele Drobnitzky (6262547)
Agata Patel (6262553)
Luiza Lourenco (6262556)
Fiona Cahill (6262562)
Yanyan Jiang (253354)
Anthony Kong (94738)
Anderson Ryan (482874)

January 2019

Figure S1. Positive correlation of pSTAT3 expression with HSP90i sensitivity. A scatter plot display...

Additional file 1: of Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina Mumin (6262541)
Neele Drobnitzky (6262547)
Agata Patel (6262553)
Luiza Lourenco (6262556)
Fiona Cahill (6262562)
Yanyan Jiang (253354)
Anthony Kong (94738)
Anderson Ryan (482874)

January 2019

Table S1. The top 20 most significantly enriched pathways seen in HSP90i-resistant clones. Pathway e...

Additional file 4: Figure S4. of PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 regulates hypoxia-induced HIF-1α accumulation. A, B, pancreatic cancer cells transduced with a ...

Additional file 4: Figure S3. of Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors

Charan Devarakonda (3587093)
Daniel Kita (3587096)
Kathryn Phoenix (3587099)
Kevin Claffey (33353)

September 2015

Immunoprecipitation of HSP90 from xenograft tumor lysates using HCAb2. RIPA lysates of xenograft tum...

Additional file 2: Table S2. of Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

Hirofumi Bekki (3501791)
Kenichi Kohashi (3501809)
Akira Maekawa (3501797)
Yuichi Yamada (3501800)
Hidetaka Yamamoto (3501794)
Katsumi Harimaya (3501803)
Michiyuki Hakozaki (582996)
Kazuki Nabeshima (3501806)
Yukihide Iwamoto (89775)
Yoshinao Oda (629764)

October 2015

Immunohistochemical Results and Their Statistical Analysis. EFS, event-free survival; LI, labeling i...

Additional file 2: of HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Xin Xiao (117295)
Wei Wang (17594)
Yuqian Li (577378)
Di Yang (126672)
Xiaokang Li (158714)
Chao Shen (520343)
Yan Liu (25061)
Xianzhu Ke (4566235)
Shuo Guo (5696564)
Zheng Guo (14989)

August 2018

Figure S2. JNK or p38 inhibitors decreased the cell apoptosis. A, control shRNA/HSP90AA1 shRNA trans...

Additional file 5: of Mutational analysis of selected high-grade malignancies in a premenopausal gynecologic cancer population: a potential for targeted therapies?

Lauren Pinckney (5712251)
Justin Collins (5712254)
Christine Schammel (5712257)
Matt Gevaert (2370316)
David Schammel (5712260)
W. Edenfield (5712263)
Jeffrey Elder (5712266)
Larry Puls (5712269)

September 2018

Figure S2. GPR124, ALK and KMT2D proteins converge on HSP90AA1. An evaluation of the potential role ...

Additional file 3: of Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina Mumin (6262541)
Neele Drobnitzky (6262547)
Agata Patel (6262553)
Luiza Lourenco (6262556)
Fiona Cahill (6262562)
Yanyan Jiang (253354)
Anthony Kong (94738)
Anderson Ryan (482874)

January 2019

Table S2. Compounds that were selectively cytotoxic to parental Hs578T cells compared with HSP90i-re...

Additional file 1: Figure S1. of Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

Gaurab Chakrabarti (3425915)
Zachary Moore (3425921)
Xiuquan Luo (579204)
Mariya Ilcheva (3425912)
Aktar Ali (412002)
Mahesh Padanad (3425930)
Yunyun Zhou (1780960)
Yang Xie (46489)
Sandeep Burma (122515)
Pier Scaglioni (3425909)
Lewis Cantley (2653345)
Ralph DeBerardinis (3425927)
Alec Kimmelman (3425933)
Costas Lyssiotis (3425918)
David Boothman (3425924)

October 2015

ß-Lap mechanism and GOT2 to GLUD1 Kaplan–Meier curve. (A) ß-lap mechanism of action. In the cytosol ...

Additional file 2: Figure S2. of GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

Hiromi Ito (505919)
Osamu Ichiyanagi (3490328)
Sei Naito (3490322)
Vladimir Bilim (3490316)
Yoshihiko Tomita (2511928)
Tomoyuki Kato (3490325)
Akira Nagaoka (3490319)
Norihiko Tsuchiya (95704)

July 2016

Different effects of GSK-3 inhibition on Akt and 4EBP1 phosphorylation. (A) ACHN cells were treated ...

Additional file 5: Figure S4. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Abstract

Extracted data

Additional file 5: Figure S4. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Abstract

Extracted data

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