FOXM1 stimulates progression of lung adenomas into mucinous adenocarcinomas.

<p>Schematic drawing shows that FOXF1 induces expression of cell-cycle regulatory and mucinous genes, including <i>Agr2</i>, causing increased tumor cell proliferation and mucinous phenotype. FOXM1 directly activates transcription of <i>Agr2</i>. Both FOXM1 and AGR2 are critical for PIMA growth, invasion and progression of lung adenomas into aggressive mucinous adenocarcinomas.