Global mapping of transcriptional regulation in human aging.

<p>Enrichment scores of prioritized transcription factor motifs, using TRANSFAC database, are visualized as a dendrogram. The heat map represents unique gene regulatory signatures of 18 human tissues and 7 cell aging experiments. Motifs enriched in aging (p<0.05) are indicated in red, and avoided motifs in green. Motifs are ranked and sorted by hierarchical clustering using Spearman rank correlation, complete linkage. Tissue samples agglomerate with either an experimental energy restriction cell model in quiescence (ERiQ, sample #4), or anti-correlate as a group of nine senescence related samples. The corresponding analysis using JASPAR motifs is provided in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190457#pone.0190457.s001" target="_blank">S1 Fig</a>.