We report the development of a method to parameterize and predict the performance of structurally flexible β-turn-containing peptide catalysts, using the atroposelective bromination of 3-arylquinazolin-4(3<i>H</i>)-ones as a case study. The multivariate correlations obtained for tetrapeptides of two β-turn types, type I′ pre-helical and type II′ β-hairpin, indicate that although one conformer may be associated with a more dominant contribution to the observed enantioselectivity, it is possible that multiple conformers contribute to a complex transition state ensemble
Among the various types of α-peptide folding motifs, δ-turn, which requires a central cis-amide disp...
b-Turns play an important role in peptide and protein chemistry, biophysics, and bioinformatics. The...
Contains fulltext : 29815.pdf (publisher's version ) (Open Access)This thesis aims...
It is widely accepted that structural rigidity is required to achieve high levels of asymmetric indu...
X-ray crystallography has been applied to the structural analysis of a series of tetrapeptides that ...
We report the development of a tertiary amine-containing β-turn peptide that catalyzes the atroposel...
Herein, we document our recent efforts to expand the scope of Bronsted base-containing peptide catal...
Peptides have become valuable as catalysts for a variety of different reactions, but little is known...
The structural analysis of a peptide-based catalyst for the Baeyer–Villiger oxidation (BVO) is repor...
Peptides have become valuable as catalysts for a variety of different reactions, but little is known...
Inspired by nature’s nonpareil catalysts, enzymes, our lab designs small peptides to catalyze select...
Peptides are intriguing catalysts because they occupy a middle ground between enzymes and small-mole...
In the present paper we describe the solution nmr structural analysis and restrained molecular dynam...
We report the design of a cyclic, eight-residue peptide that possesses the catalytic triad residues ...
Intramolecular side-chain to side-chain cyclization is an established approach to achieve stabilizat...
Among the various types of α-peptide folding motifs, δ-turn, which requires a central cis-amide disp...
b-Turns play an important role in peptide and protein chemistry, biophysics, and bioinformatics. The...
Contains fulltext : 29815.pdf (publisher's version ) (Open Access)This thesis aims...
It is widely accepted that structural rigidity is required to achieve high levels of asymmetric indu...
X-ray crystallography has been applied to the structural analysis of a series of tetrapeptides that ...
We report the development of a tertiary amine-containing β-turn peptide that catalyzes the atroposel...
Herein, we document our recent efforts to expand the scope of Bronsted base-containing peptide catal...
Peptides have become valuable as catalysts for a variety of different reactions, but little is known...
The structural analysis of a peptide-based catalyst for the Baeyer–Villiger oxidation (BVO) is repor...
Peptides have become valuable as catalysts for a variety of different reactions, but little is known...
Inspired by nature’s nonpareil catalysts, enzymes, our lab designs small peptides to catalyze select...
Peptides are intriguing catalysts because they occupy a middle ground between enzymes and small-mole...
In the present paper we describe the solution nmr structural analysis and restrained molecular dynam...
We report the design of a cyclic, eight-residue peptide that possesses the catalytic triad residues ...
Intramolecular side-chain to side-chain cyclization is an established approach to achieve stabilizat...
Among the various types of α-peptide folding motifs, δ-turn, which requires a central cis-amide disp...
b-Turns play an important role in peptide and protein chemistry, biophysics, and bioinformatics. The...
Contains fulltext : 29815.pdf (publisher's version ) (Open Access)This thesis aims...