<p><b>(A)</b> Expression of innate immune receptors and of <b>(B)</b> signal transduction molecules of respective pathways (indicated in brackets) involved in M1 polarization analyzed 4 days after stroke in the perilesional areas of the ischemic hemisphere. <b>(C)</b> Quantification of CD8+CD68+ cells as average (Av) counts ± SEM per field of 0.125 mm<sup>2</sup> <b>(D)</b> Proportion of CD68+ cells expressing CD8 for MCAO animals. Sham animals are not plotted that lacked either or both CD8+ or CD68+ cells showed ratio was either 0 or a/0. <i>A</i>-<i>D</i>: Data are presented as mean ± SEM. * <i>P</i> < 0.05; ** <i>P</i> < 0.01; *** <i>P</i> < 0.001.</p
Stroke induces a robust inflammatory response. However, it still lacks a systematic view of the vari...
Stroke is a multiphasic process, and the initial ischemic phase of neuronal damage is followed by se...
<p>(<b>A</b>) Frequency of TNF-α positive brain microglia in wt and <i>Ns<sup>−/−</sup></i> mice ana...
<p><b>(A–B)</b> Upper panel shows representative triple-labeled immunostaining of CD8+CD68+ cells ex...
© 2011 Dr. Catherine DownesThe response to the hypoxia and ischemia that occurs in the CNS during an...
<p>A. The WT ipsilateral hemispheres display more cells positive for leukocyte esterases than the <i...
<p><b>A.</b> Post-ischemic Iba1 positive cells (green) displayed the typical activated amoeboid phen...
<p><b>A.</b> CD3-positive T-cells invaded the infarct core at 7 d and 28 d following stroke. Increas...
BACKGROUND: Converging evidence suggests that inflammatory processes significantly influence brain i...
Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS an...
<p>A. Representative infarctions in the cortex are shown. Animals were euthanized 3 d after stroke. ...
<p>(<b>A</b> and <b>B</b>) Relative expression of <i>Il1b</i>, <i>Tnfa</i>, and <i>Il10</i> mRNAs in...
<p><b>Fluorescence labeling of the immune cell markers CD68 and Iba combined with GFAP-immunodetecti...
Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS an...
Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS an...
Stroke induces a robust inflammatory response. However, it still lacks a systematic view of the vari...
Stroke is a multiphasic process, and the initial ischemic phase of neuronal damage is followed by se...
<p>(<b>A</b>) Frequency of TNF-α positive brain microglia in wt and <i>Ns<sup>−/−</sup></i> mice ana...
<p><b>(A–B)</b> Upper panel shows representative triple-labeled immunostaining of CD8+CD68+ cells ex...
© 2011 Dr. Catherine DownesThe response to the hypoxia and ischemia that occurs in the CNS during an...
<p>A. The WT ipsilateral hemispheres display more cells positive for leukocyte esterases than the <i...
<p><b>A.</b> Post-ischemic Iba1 positive cells (green) displayed the typical activated amoeboid phen...
<p><b>A.</b> CD3-positive T-cells invaded the infarct core at 7 d and 28 d following stroke. Increas...
BACKGROUND: Converging evidence suggests that inflammatory processes significantly influence brain i...
Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS an...
<p>A. Representative infarctions in the cortex are shown. Animals were euthanized 3 d after stroke. ...
<p>(<b>A</b> and <b>B</b>) Relative expression of <i>Il1b</i>, <i>Tnfa</i>, and <i>Il10</i> mRNAs in...
<p><b>Fluorescence labeling of the immune cell markers CD68 and Iba combined with GFAP-immunodetecti...
Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS an...
Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS an...
Stroke induces a robust inflammatory response. However, it still lacks a systematic view of the vari...
Stroke is a multiphasic process, and the initial ischemic phase of neuronal damage is followed by se...
<p>(<b>A</b>) Frequency of TNF-α positive brain microglia in wt and <i>Ns<sup>−/−</sup></i> mice ana...