Additional file 1: Figure S1. of Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis

Funnel plots for ET, isotime IC and isotime dyspnea. Figure S2A Forest and Funnel plots of ET, isotime IC and isotime dyspnea in the 11 studies which included only COPD patients with functional residual capacity (FRC) > 120%. Figure S2B Forest and Funnel plots of ET, isotime IC and isotime dyspnea in the 11 studies which did not require an increase of functional residual capacity (FRC) as inclusion criterion (i.e. unselected COPD patients). Figure S3 Forest and Funnel plots of ET of the 5 studies (A) which used walking, and 17 studies (B) which used cycling as exercise methodology to assess the efficacy of long-acting bronchodilators. Table S1 Cochrane collaboration tool for assessing risk of bias. (DOCX 545 kb