Pharmacokinetic properties of HC-070.

<p>PK profiles of HC-070 after intravenous (A) and oral (B) administration in C57BL/6 mice. Plasma concentrations were determined by LC-MS/MS. Points represent the individual concentrations at the times indicated. Lines represent mean exposure (n = 12 mice/arm, n = 3 data points per time point). (C) Summary of PK properties. CL = clearance; V_ss = volume of distribution at steady state; MRT_disp = mean residence time of drug molecules after intravascular administration; T_1/2 = half-life. (D) Plasma and brain concentrations measured 2 hours after intravenous or oral administration of 1 or 10 mg/kg HC-070, respectively. C_PL = concentration in plasma, C_BR = concentration in brain, K_P,BR = partitioning coefficient between brain and plasma.