Characterization of the infectivity of recPrP^Sc.

<p>A<b>)</b> Kaplan-Meier survival plots of Tga20 mice inoculated with recMoPrP^Sc. B) Histopathological and immunohistochemical analysis of brains fromTga20 mice inoculated with recMoPrP^Sc and uninoculated tga20 controls: left: haematoxylin-eosin (H&E) staining of the medulla oblongata, notice the spongiform lesion in the inoculated mice (bottom); right: PrP^Sc IHC staining (antibody 2G11, epitope: 151–159) of the medulla oblongata showing fine granular PrP^Sc deposits in the inoculated mice (bottom). C) WB showing the presence of PK-resistant PrP in the brains of Tga20 mice inoculated with recMoPrP^Sc.