Gene regulation by MALAT-1.

<p>(A) Panc1 cells were transfected with oligonucleotides (siMALAT-1#1/siMALAT-1#2) and expression of MALAT-1 was determined by real time PCR. (B) Panc1 cells were transfected with siMALAT-1 or siCtrl and gene expression was analyzed using Human HT-12 v4 expression beadchip (Illumina, Inc.) array. (C) The effects of siMALAT-1 on different function categories and the predicted activation state of cell proliferation, death and movement after HOTTIP knockdown were determined by IPA. (D) Pathway analysis. Causal IPA was used to analyze the p-values and Z-scores for cell movement proliferation and cell death after MALAT-1 knockdown by RNA interference.