Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations - Fig 2

<p><b>Meta-analysis of site-specific interaction between SNP variant allele, aspirin-only use and (A) colon cancer risk and (B) rectal cancer risk</b>. (<b>A</b>) Association between <i>UGT1A6</i> rs2070959 (T181A) variant allele and colon cancer risk stratified by aspirin use (<i>P</i>_interaction = 0.006); association between <i>UGT1A7</i> rs1105879 (R184S) variant allele and colon cancer risk stratified by aspirin use (<i>P</i>_interaction = 0.008). (<b>B</b>) Association between <i>UGT1A6</i> rs2070959 (T181A) variant allele and rectal cancer risk stratified by aspirin use (<i>P</i>_interaction = 0.22); association between <i>UGT1A6</i> rs1105879 (R184S) variant allele and rectal cancer risk stratified by aspirin use (<i>P</i>_interaction = 0.26). Forest plot depicting meta-analysis odds ratio of gene x environment interaction term. I-squared is the measure of the variation in odds ratio attributable to heterogeneity [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192223#pone.0192223.ref030" target="_blank">30</a>] and <i>P</i>-value tests for heterogeneity between the UK-CCSG and NIH-CCFR datasets. <i>*P-</i>value for association <0.05; CC: Colon Cancer; RC: Rectal Cancer; UK-CCSG: UK-Colorectal Cancer Study Group; NIH-CCFR: NIH-Colon Cancer Family Registry.