FV-DC from mice with different H-2 genotypes show converging FV-induced expression of groups of interacting proteins that regulate key cell functions.

<p>FV-DC were generated as described. On day 6 of culture, cytoplasmic protein was extracted form immature BM-DC (uninfected and FV-infected) and was subjected to label-free protein mass spectroscopy. (A) Heat map of cytoplasmic proteins concurrently regulated in FV-DC versus Ctrl-DC in a genotype-independent manner (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192541#pone.0192541.s006" target="_blank">S1 File</a>). (B-D) Subsets of proteins that are regulated in a concurrent fashion in both mouse strains (as shown in A) were grouped according to their primary function, namely (B) metabolism, (C) cytoskeletal organization, and (D) MHC-II biology. (B-D) The probability of protein-protein interaction correlates with the thickness of their connection lines.