The effect of magnolol on plasma triglyceride level in mice.

<p>Human <i>APOA5</i> c.553G>T knock-in male 12-week-old B6 mice were divided into wild-type (n = 11) (A), heterozygous (n = 15) (B) and homozygous (n = 7) (C) groups. A corn oil bolus (6 ml/kg) or magnolol (30 mg/kg; 30 μg/μL in corn oil) was administered by oral gavage once daily for 4 days. On the fourth day, 2 h after feeding, knock-in mice were anesthetized using avertin and heparinized blood was collected via inferior vena cava for determination of lipid concentrations. Statistical analysis was performed using Mann-Whitney U test. * <i>p</i><0.05; ** <i>p</i><0.001.