Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells.
- Strandin, Tomas
- Hepojoki, Jussi
- Wang, Hao
- Vaheri, Antti
- Lankinen, Hilkka
Publication date
November 2008
DOI Publisher
Springer Science and Business Media LLCAbstract
BACKGROUND: We have previously reported that the apathogenic Tula hantavirus induces apoptosis in Vero E6 epithelial cells. To assess the molecular mechanisms behind the induced apoptosis we studied the effects of hantavirus infection on cellular signaling pathways which promote cell survival. We previously also observed that the Tula virus-induced cell death process is augmented by external TNF-a ... [More
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