The Interaction of Polyglutamine Peptides with Lipid Membranes Is Regulated by Flanking Sequences Associated with Huntingtin
- Burke, Kathleen A.
- Kauffman, Karlina J.
- Umbaugh, Samuel
- Frey, Shelli L.
- Legleiter, Justin
Publication date
May 2013
DOI Publisher
The Cupola: Scholarship at Gettysburg College ISSN
0021-9258 Citation count (estimate)
38Abstract
Background: Huntington disease (HD) is caused by an expanded polyglutamine (polyQ) domain in huntingtin (htt), leading to aggregation. Results: Specific flanking sequences adjacent to the polyQ domain modulate htt aggregation on lipid bilayers. Conclusion: Lipid mediated htt aggregation may lead to membrane dysfunction in HD. Significance: Flanking sequences may play a role in membrane dysfunction associated with Huntington disease
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