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Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences

  • Kim, KT
  • Veedu, RN
  • Seoc, YJ
  • Kim, BH
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Icon DOI
10.1039/C3CC48853E
Publisher
Royal Society of Chemistry (RSC)
Journal
Chemical Communications

Abstract

We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of their U-Py units.open111214sciescopu

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