A universal adjacency matrix U of a graph G is a linear combination of the 0–1 adjacency matrix A, the diagonal matrix of vertex degrees D, the identity matrix I and the matrix J each of whose entries is 1. A main eigenvalue of U is an eigenvalue having an eigenvector that is not orthogonal to the all–ones vector. It is shown that the number of distinct main eigenvalues of U associated with a simple graph G is at most the number of orbits of any automorphism of G. The definition of a U–controllable graph is given using control–theoretic techniques and several necessary and sufficient conditions for a graph to be U–controllable are determined. It is then demonstrated that U–controllable graphs are asymmetric and that the converse is false, s...