Qualified difference sets are a class of combinatorial configuration. The sets are related to the residue difference sets that were first discussed in detail in 1953 by Emma Lehmer. Qualified difference sets consist of a set of residues modulo an integer v and they possess attractive properties that suggest potential applications in areas such as image formation, signal processing and aperture synthesis. This thesis outlines the theory behind qualified difference sets and gives conditions for the existence and nonexistence of these sets in various cases. A special case of the qualified difference sets is the qualified residue difference sets. These consist of the set of nth power residues of certain types of prime. Necessary and su...