Uji Efektivitas Ekstrak Etanol 70% Lidah Buaya (Aloe Vera L.) Terhadap Penurunan Kadar LDL Pada Tikus (Rattus Norvegicus) Putih Jantan Hiperkolesterolemia

Aloe vera extracts (Aloe vera L.) can reduce LDL levels because it contains acemannan (glucomannan) active substances and cellulose. The active substances work by inhibiting cholesterol synthesis in the gut. The aim of this study was to study the effectiveness of Aloe vera L. extracts which can lower LDL levels in white male rat (Rattus norvegicus). This research is a laboratory experimental research with pre and post test method and control group design. The study was conducted on 25 white male rats (Rattus norvegicus) induced with high-fat diet for 14 days. Subjects were divided into 5 groups, namely: negative control group, positive control group (Cholestyramine 0.2g/200gBW/day), treatment group 1 (0.3 g/200 gBW/day), treatment group 2 (0.6 g/200 gBW/day) and treatment group 3 (1.2 g/200 gBW/day). Measurements of LDL cholesterol were performed on day 7, day 21, and day 35. Based on the result of post hoc statistic test, obtained (p