Formulasi Sediaan Krim Minyak Atsiri Kayu Manis (Cinnamomum burmannii) Dengan Basis Vanishing Cream Dan Uji Aktivitas Antibakterinya Terhadap Staphylococcus epidermidis

One of the potential causes of acne is bacterium Staphylococcus epidermidis. Cinnamon essential oil contains sinamaldehid and eugenol which has benefit as an anti-bacterial agent. This study has purpose to determine the effect of cera alba and vaselinum album proportion on the physical properties, physical stability, anti bacterial activity toward Staphylococcus epidermidis. The essential oil of cinnamon was obtained by steam distillation. The chemical content of sinamaldehid and eugenol in the essential oil was tested by using TLC. The formula of cream was made with various composition of variation cera alba : vaselinum album. They were F1 (30%:70%), F2 (40%:60%), F3 (50%:50%), F4 (60%:40%), and F5 (70%:30%) respectively. The test of the physical properties of cream includes viscosity, spreadibility, adhesion, and the test of physical stability of cream has done by using freeze thaw cycling. The test of anti-bacterial activity was performed by pitting diffusion method. The effect of freeze thaw was analyzed by using multivariate analysis, the physical properties were analyzed by using anova test, the antibacterial test of before and after freeze thaw and the test of physical stability of cream in the cycle of 0 and 6 were analyzed by using paired sample t-test. The results indicate that the cream increased in viscosity and adhesion, decreased cream spreadibility, by the increase of cera alba in cream. Freeze thaw cycling test caused lowering viscosity of all formulas and decreasing spreadibility of F2, but increasing adhesion of F1. There is no different of antibacterial activity before and after freeze thaw cycling test