Ceruloplasmin (CP) is essential for brain iron homeostasis. However, its precise function in brain iron transport has not been definitely determined. In this study, we investigated the effects of soluble CP on iron influx and efflux in primary neuronal culture from the midbrain (the substantia nigra and striatum) and the hippocampus. Our data showed that low concentrations of CP (2,4,8 μg/ml) can promote iron influx into iron-deficient neurons, but not the neurons with normal iron status. The same concentrations of CP had no effect on iron efflux from iron-sufficient and normal-iron neurons. Contrary to our expectation, we did not find any regional difference in the effects of CP on iron influx as well as efflux in neurons. The changes in q...
Ceruloplasmin (Cp) is a ferroxidase that also plays a role in iron efflux from cells. It can thus he...
Elevated iron levels are considered to play a role in the neurodegenerative mechanisms that underlie...
The mechanisms for iron transport through the blood-brain barrier (BBB) remain a controversy. We ana...
Ceruloplasmin (CP) is essential for brain iron homeostasis. However, little is known about the effec...
Iron is an essential metal for living organisms. It is, however, a redox active metal and hence its ...
The 9th National Conference on Neuroendocrinology of Chinese Association of Physiological Sciences, ...
Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficki...
Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficki...
373 leaves : ill. ; 30 cm.PolyU Library Call No.: [THS] LG51 .H577P ABCT 2003 ChangCeruloplasmin (CP...
In a previous study, we found that human ceruloplasmin (hCP) promotes iron uptake rather than releas...
Ceruloplasmin oxidizes the toxic ferrous (Fe(II)) form of iron to the ferric (Fe(III)) form, and pro...
AbstractCeruloplasmin plays an essential role in cellular iron efflux by oxidizing ferrous iron expo...
SummaryFerroxidases are essential for normal iron homeostasis in most organisms. The paralogous vert...
SummaryFerroxidases are essential for normal iron homeostasis in most organisms. The paralogous vert...
Elevated iron levels are considered to play a role in the neurodegenerative mechanisms that underlie...
Ceruloplasmin (Cp) is a ferroxidase that also plays a role in iron efflux from cells. It can thus he...
Elevated iron levels are considered to play a role in the neurodegenerative mechanisms that underlie...
The mechanisms for iron transport through the blood-brain barrier (BBB) remain a controversy. We ana...
Ceruloplasmin (CP) is essential for brain iron homeostasis. However, little is known about the effec...
Iron is an essential metal for living organisms. It is, however, a redox active metal and hence its ...
The 9th National Conference on Neuroendocrinology of Chinese Association of Physiological Sciences, ...
Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficki...
Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficki...
373 leaves : ill. ; 30 cm.PolyU Library Call No.: [THS] LG51 .H577P ABCT 2003 ChangCeruloplasmin (CP...
In a previous study, we found that human ceruloplasmin (hCP) promotes iron uptake rather than releas...
Ceruloplasmin oxidizes the toxic ferrous (Fe(II)) form of iron to the ferric (Fe(III)) form, and pro...
AbstractCeruloplasmin plays an essential role in cellular iron efflux by oxidizing ferrous iron expo...
SummaryFerroxidases are essential for normal iron homeostasis in most organisms. The paralogous vert...
SummaryFerroxidases are essential for normal iron homeostasis in most organisms. The paralogous vert...
Elevated iron levels are considered to play a role in the neurodegenerative mechanisms that underlie...
Ceruloplasmin (Cp) is a ferroxidase that also plays a role in iron efflux from cells. It can thus he...
Elevated iron levels are considered to play a role in the neurodegenerative mechanisms that underlie...
The mechanisms for iron transport through the blood-brain barrier (BBB) remain a controversy. We ana...