Neuropeptide FF (NPFF) belongs to an opioid-modulating peptide family. NPFF has been reported to play important roles in the control of pain and analgesia through interactions with the opioid system. However, very few studies examined the effect of supraspinal NPFF system on analgesia induced by opiates administered at the peripheral level. In the present study, intracerebroventricular (i.c.v.) injection of NPFF (1, 3 and 10 nmol) dose-dependently inhibited systemic morphine (0.12 mg, i.p.) analgesia in the mouse tail flick test. Similarly, i.c.v. administration of dNPA and NPVF, two agonists highly selective for NPFF2 and NPFF1 receptors, respectively, decreased analgesia induced by i.p. morphine in mice. Furthermore, these anti-opioid act...
A structure-activity study was carried out to determine the importance of the C-terminal amino acids...
Our main purpose was to evaluate the influence of cancer pain on the rewarding properties of morphin...
The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronocicep...
Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very fe...
BACKGROUND AND PURPOSE Opiates remain the most effective compounds for alleviating severe pain acros...
Although opiates represent the most effective analgesics, their use in chronic treatments is associa...
Although opiates represent the most effective analgesics, their use in chronic treatments is associa...
Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system which h...
AbstractNeuropeptide FF (NPFF) modulates opiate actions. It has pro-nociceptive effects, primarily t...
The newly discovered neuropeptide nociceptin (NC) has recently been reported to be the endogenous li...
<p>(A) Dose-related effects of NPFF (3, 10 and 15 nmol) on the central antinociception of U69593. (B...
Neuropeptide FF (NPFF) is a neuromediator modulating opioid system activity. To determine brain regi...
<p>(A) NPVF (3, 10 and 15 nmol) and (B) dNPA (3, 10 and 15 nmol) potentiated EM-1(7.5 nmol) induced ...
Mammalian RF-amide peptides are encoded by five different genes and act through five different G pro...
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain man...
A structure-activity study was carried out to determine the importance of the C-terminal amino acids...
Our main purpose was to evaluate the influence of cancer pain on the rewarding properties of morphin...
The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronocicep...
Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very fe...
BACKGROUND AND PURPOSE Opiates remain the most effective compounds for alleviating severe pain acros...
Although opiates represent the most effective analgesics, their use in chronic treatments is associa...
Although opiates represent the most effective analgesics, their use in chronic treatments is associa...
Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system which h...
AbstractNeuropeptide FF (NPFF) modulates opiate actions. It has pro-nociceptive effects, primarily t...
The newly discovered neuropeptide nociceptin (NC) has recently been reported to be the endogenous li...
<p>(A) Dose-related effects of NPFF (3, 10 and 15 nmol) on the central antinociception of U69593. (B...
Neuropeptide FF (NPFF) is a neuromediator modulating opioid system activity. To determine brain regi...
<p>(A) NPVF (3, 10 and 15 nmol) and (B) dNPA (3, 10 and 15 nmol) potentiated EM-1(7.5 nmol) induced ...
Mammalian RF-amide peptides are encoded by five different genes and act through five different G pro...
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain man...
A structure-activity study was carried out to determine the importance of the C-terminal amino acids...
Our main purpose was to evaluate the influence of cancer pain on the rewarding properties of morphin...
The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronocicep...