The sound generated by a vortex propagating across a two-dimensional duct section with flexible walls (membranes) in an infinitely long rigid duct conveying a flow is investigated numerically using the matched asymptotic expansion technique and the potential theory. The effects of the initial vortex position, the mechanical properties of the flexible walls, and the mean flow on the sound generation are examined in detail. Results show that the presence of a vortex inside a uniform mean flow can strengthen or attenuate the sound generation, depending on the phase of the membrane vibration when the vortex starts vigorous interaction with the membranes and the strength of the mean flow. The results tend to imply that there is a higher chance o...