Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins, either detoxifying reactive oxygen species or acting as chaperones to prevent protein aggregation. Several stimuli, including peroxide-mediated sulfinic acid formation at the active site cysteine, have been proposed to trigger the chaperone activity. However, the mechanism underlying this activation and the extent to which the chaperone function is crucial under physiological conditions in vivo remained unknown. Here we demonstrate that in the vector-borne protozoan parasite Leishmania infantum, mitochondrial peroxiredoxin (Prx) exerts intrinsic ATP-independent chaperone activity, protecting a wide variety of different proteins against heat...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Molecular chaperones are key components in the maintenance of cellular homeostasis and survival, not...
Metacaspases are cysteine peptidases that could play a role similar to caspases in the cell death pr...
Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins...
Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins...
Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins...
Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leis...
Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as peroxidases unde...
Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leis...
Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as peroxidases unde...
Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as peroxidases unde...
Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leis...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Molecular chaperones are key components in the maintenance of cellular homeostasis and survival, not...
Metacaspases are cysteine peptidases that could play a role similar to caspases in the cell death pr...
Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins...
Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins...
Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins...
Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leis...
Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as peroxidases unde...
Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leis...
Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as peroxidases unde...
Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as peroxidases unde...
Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leis...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved...
Molecular chaperones are key components in the maintenance of cellular homeostasis and survival, not...
Metacaspases are cysteine peptidases that could play a role similar to caspases in the cell death pr...