pEapfefricient Synthesis of Imidazole-Fused Benzodiazepines Using Palladium- Catalyzed Intramolecular C–N Bond Formation Reaction

An efficient three-step synthetic route to imidazolefused benzodiazepines from imidazole-2-carbaldehyde is described. Application of intramolecular Buchwald–Hartwig cycloamination reaction in the final step is shown to be a convenient method for the synthesis of fused seven-membered diazacycles. The reactions proceeded smoothly with both aliphatic and aromatic amines. Key words: palladium, catalysis, amination, cyclization, benzodiazepin