Clinical evidence suggests an association between galactosaemia and premature ovarian insufficiency (POI); however, the mechanism still remains unresolved. Experimental galactose toxicity in rats produces an array of ovarian dysfunction including ovarian development with deficient follicular reserve and follicular resistance to gonadotrophins that characterize the basic tenets of human POI. The present investigation explores if galactose toxicity in rats attenuates the bioactivity of gonadotrophins or interferes with their receptor competency, and accelerates the rate of follicular atresia. Pregnant rats were fed isocaloric food-pellets supplemented with or without 35% D-galactose from day-3 of gestation and continuing through weaning...
BACKGROUND: Hypergonadotropic hypogonadism is a burdensome complication of classic galactosemia (CG)...
Preovulatory follicular atresia was studied using pregnant mare serum gonadotropin (PMSG)-primed rat...
The changes that occur during follicular growth and atresia in the lysosomal enzyme activities and i...
In rats, prenatal exposure to high concentrations of galactose may contribute to a condition that i...
Galactosemia is a genetic disease with deficiency of galactose-1-uridyltransferase, resulting in the...
Background: Premature ovarian insufficiency (POI) affects about 1% of women of reproductive ages (15...
Premature ovarian insufficiency (POI) is a frequent long-term complication of classic galactosemia. ...
Background: Premature ovarian insufficiency (POI) affects about 1% of women of reproductive ages (15...
Classic galactosemia is an inborn error of carbohydrate metabolism associated with early-onset prima...
Hypergonadotropic hypogonadism in two sisters with galactosaemia 783 well as galactitol concentratio...
Galactosemia is a rare, debilitating metabolic disorder whereby the body cannot effectively metaboli...
FSH inactivity due to secondary hypoglycosylation has been suggested as a potential mechanism for pr...
FSH inactivity due to secondary hypoglycosylation has been suggested as a potential mechanism for pr...
Primary or premature ovarian insufficiency (POI) is the most common long-term complication experienc...
Classic galactosemia results from deficient activity of galactose-1-phosphate uridylyltransferase (G...
BACKGROUND: Hypergonadotropic hypogonadism is a burdensome complication of classic galactosemia (CG)...
Preovulatory follicular atresia was studied using pregnant mare serum gonadotropin (PMSG)-primed rat...
The changes that occur during follicular growth and atresia in the lysosomal enzyme activities and i...
In rats, prenatal exposure to high concentrations of galactose may contribute to a condition that i...
Galactosemia is a genetic disease with deficiency of galactose-1-uridyltransferase, resulting in the...
Background: Premature ovarian insufficiency (POI) affects about 1% of women of reproductive ages (15...
Premature ovarian insufficiency (POI) is a frequent long-term complication of classic galactosemia. ...
Background: Premature ovarian insufficiency (POI) affects about 1% of women of reproductive ages (15...
Classic galactosemia is an inborn error of carbohydrate metabolism associated with early-onset prima...
Hypergonadotropic hypogonadism in two sisters with galactosaemia 783 well as galactitol concentratio...
Galactosemia is a rare, debilitating metabolic disorder whereby the body cannot effectively metaboli...
FSH inactivity due to secondary hypoglycosylation has been suggested as a potential mechanism for pr...
FSH inactivity due to secondary hypoglycosylation has been suggested as a potential mechanism for pr...
Primary or premature ovarian insufficiency (POI) is the most common long-term complication experienc...
Classic galactosemia results from deficient activity of galactose-1-phosphate uridylyltransferase (G...
BACKGROUND: Hypergonadotropic hypogonadism is a burdensome complication of classic galactosemia (CG)...
Preovulatory follicular atresia was studied using pregnant mare serum gonadotropin (PMSG)-primed rat...
The changes that occur during follicular growth and atresia in the lysosomal enzyme activities and i...